PGx-SUPPORT
In any given year, mental illness affects 6.7 million people in Canada, costing approximately $50 billion annually to the Canadian healthcare and social support system. Between 2010 and 2015, 28% of Manitoba adults (that’s about 267,000 of us) were living with at least one mental illness and 23% were diagnosed with a mood and anxiety disorder specifically. Depression alone adds a total average cost of $8,244 (standard deviation: $40,542) per person annually in Manitoba regarding health care utilization and social services costs. For individuals with moderate to severe mental illness, psychotropics are commonly prescribed medications as either the sole form of treatment or in combination with psychotherapy. Unfortunately, randomized controlled trials have shown that about one-third of individuals with major depressive disorder do not achieve symptom remission when treated according to protocol-based care. Finding suitable psychotropic medicines that work for an individual is clinically challenging and can take months to years, leading to non-adherence and treatment failure. This has potentially devastating consequences for the affected person, their family, and society. As such, there is a need for additional prescribing strategies that can augment current treatment protocols and boost effective medication management of psychiatric disorders. Pharmacogenomic (PGx) testing is one such strategy that utilizes genetic information as a surrogate marker of a person's ability to process and react to drugs. This information can inform psychotropic medication selection and dosing, reducing the number of trials needed to choose a suitable medicine.
Objective:
We aim to investigate the feasibility of implementing pharmacogenomic (PGx) testing for adult patients seeking care for mental illness on Inpatient Mental Health Units in Manitoba.
Inclusion criteria: Participants will be eligible for participation if all the following are true:
Exclusion criteria: Participants will be excluded from participation if any of the following are true:
Objective:
We aim to investigate the feasibility of implementing pharmacogenomic (PGx) testing for adult patients seeking care for mental illness on Inpatient Mental Health Units in Manitoba.
Inclusion criteria: Participants will be eligible for participation if all the following are true:
- Presented for services within any inpatient units in Manitoba
- Age 25 years or older
- The initiation, change, dose adjustment, or augmentation of psychotropic medication(s) is indicated
- The treating clinician thinks PGx testing can benefit the patient and refers the patient to the PRECISE-CaRE Hub
Exclusion criteria: Participants will be excluded from participation if any of the following are true:
- Medically unstable or lacking the capacity to provide informed consent
- Unwillingness to donate saliva sample for genetic analysis
- History of liver or bone marrow (hematopoietic cell) transplantation
- PGx testing results are already available
- No personal health identification number (PHIN) is available
Team:
Principal Investigator:
Abdullah Al Maruf, PhD, M.Pharm (University of Manitoba)
Co-investigators/Collaborators:
Jitender Sareen, MD, FRCPC (University of Manitoba)
Chad Bousman, PhD, MPH (University of Calgary)
Murray Enns, MD, FRCPC (University of Manitoba)
Ruth Ann Marrie (Dalhousie University)
Renée El-Gabalawy, MA, PhD, C.Psych (University of Manitoba)
Sina Hafizi Barjin, MD (University of Manitoba)
Vishal Raj Kaushik, MD (University of Manitoba)
Alexander Singer, MB BAO BCh. CCFP (University of Manitoba)
Paul Arnold, MD, PhD, FRCPC (University of Calgary)
David Oslin, MD (University of Pennsylvania)
Jaclyn To, BScPharm, ACPR (WRHA Pharmacy Program)
Erin Ramalho, BScPharm, BCPP, EPPh (Brandon Regional Health Centre)
Daniel Yaworski, MD (University of Manitoba)
Femi Afolabi, MD (Brandon Regional Health Centre)
Ranjit Tatineni, MD (University of Manitoba)
Christine Leong, PharmD, BScPharm (University of Manitoba)
Kaarina Kowalec, PhD, MSc (University of Manitoba)
Research Pharmacist:
Anju Sareen, BSc(Pharm), RPh (University of Manitoba)
Research Nurse:
Laina McAusland, RN, MSc (University of Calgary)
Clinical Research Coordinator:
Madison Heintz, MSW, RSW (University of Calgary)
Research Assistants:
Nuzhat Tabassum, MSc Student (University of Manitoba)
Grace Pilkey, PharmD Student (University of Manitoba)
Haley Charbonneau, PharmD Student (University of Manitoba)
Abdullah Al Maruf, PhD, M.Pharm (University of Manitoba)
Co-investigators/Collaborators:
Jitender Sareen, MD, FRCPC (University of Manitoba)
Chad Bousman, PhD, MPH (University of Calgary)
Murray Enns, MD, FRCPC (University of Manitoba)
Ruth Ann Marrie (Dalhousie University)
Renée El-Gabalawy, MA, PhD, C.Psych (University of Manitoba)
Sina Hafizi Barjin, MD (University of Manitoba)
Vishal Raj Kaushik, MD (University of Manitoba)
Alexander Singer, MB BAO BCh. CCFP (University of Manitoba)
Paul Arnold, MD, PhD, FRCPC (University of Calgary)
David Oslin, MD (University of Pennsylvania)
Jaclyn To, BScPharm, ACPR (WRHA Pharmacy Program)
Erin Ramalho, BScPharm, BCPP, EPPh (Brandon Regional Health Centre)
Daniel Yaworski, MD (University of Manitoba)
Femi Afolabi, MD (Brandon Regional Health Centre)
Ranjit Tatineni, MD (University of Manitoba)
Christine Leong, PharmD, BScPharm (University of Manitoba)
Kaarina Kowalec, PhD, MSc (University of Manitoba)
Research Pharmacist:
Anju Sareen, BSc(Pharm), RPh (University of Manitoba)
Research Nurse:
Laina McAusland, RN, MSc (University of Calgary)
Clinical Research Coordinator:
Madison Heintz, MSW, RSW (University of Calgary)
Research Assistants:
Nuzhat Tabassum, MSc Student (University of Manitoba)
Grace Pilkey, PharmD Student (University of Manitoba)
Haley Charbonneau, PharmD Student (University of Manitoba)
Recruitment materials are prepared by Grace Pilkey (Research Assistant).
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