Ways to Participate/Refer:
Healthcare professionals: If you wish to refer a participant, please review the study's eligibility criteria, as outlined below. Please send the name, email address (or phone number) of the participant with their verbal consent to contact or request that they contact us directly at [email protected] If the participant or their caregiver has no access to emails, please contact us so that we can discuss how our research assistants can obtain consent, complete questionnaires, and collect saliva samples for testing. You need to complete two short surveys: one at baseline and the other within two weeks after the patient is discharged from the inpatient unit or after 3 months.
Potential participants: Please review the eligibility criteria mentioned below and fill out this form if you are interested in participating: https://redcap.link/pgx-support
Please note that you need to request your treating healthcare practitioners to refer you to the study. The treating clinician needs to be on board before we enrol you to the study. No medication changes should be made without consulting your treating doctor.
You can download (click on the link) the following poster and patient brochure to you treating doctor.
Healthcare professionals: If you wish to refer a participant, please review the study's eligibility criteria, as outlined below. Please send the name, email address (or phone number) of the participant with their verbal consent to contact or request that they contact us directly at [email protected] If the participant or their caregiver has no access to emails, please contact us so that we can discuss how our research assistants can obtain consent, complete questionnaires, and collect saliva samples for testing. You need to complete two short surveys: one at baseline and the other within two weeks after the patient is discharged from the inpatient unit or after 3 months.
Potential participants: Please review the eligibility criteria mentioned below and fill out this form if you are interested in participating: https://redcap.link/pgx-support
Please note that you need to request your treating healthcare practitioners to refer you to the study. The treating clinician needs to be on board before we enrol you to the study. No medication changes should be made without consulting your treating doctor.
You can download (click on the link) the following poster and patient brochure to you treating doctor.
Finding suitable psychotropic medicines that work for an individual is clinically challenging and can take months to years, leading to non-adherence and treatment failure. This has potentially devastating consequences for the affected person, their family, and society. As such, there is a need for additional prescribing strategies that can augment current treatment protocols and boost effective medication management of psychiatric disorders. Pharmacogenomic (PGx) testing is one such strategy that utilizes genetic information as a surrogate marker of a person's ability to process and react to drugs. This information can inform psychotropic medication selection and dosing, reducing the number of trials needed to choose a suitable medicine.
Objective:
We aim to investigate the feasibility and utility of implementing pharmacogenomic (PGx) testing for adult patients seeking care for mental illness in Manitoba. We are recruiting participants from inpatient units, outpatient settings, long-term care facilities, and primary care.
We will provide the participant and their treating doctor with an evidence-based PGx test report at no cost to the participant. The participants will also be compensated for their time for participating in the study.
Inclusion criteria: Participants will be eligible for participation if all the following are true:
Exclusion criteria: Participants will be excluded from participation if any of the following are true:
Objective:
We aim to investigate the feasibility and utility of implementing pharmacogenomic (PGx) testing for adult patients seeking care for mental illness in Manitoba. We are recruiting participants from inpatient units, outpatient settings, long-term care facilities, and primary care.
We will provide the participant and their treating doctor with an evidence-based PGx test report at no cost to the participant. The participants will also be compensated for their time for participating in the study.
Inclusion criteria: Participants will be eligible for participation if all the following are true:
- Age 18 years or older
- The initiation, change, dose adjustment, or augmentation of psychotropic medication(s) is indicated
- The treating clinician thinks PGx testing can benefit the patient and refers the patient for testing
Exclusion criteria: Participants will be excluded from participation if any of the following are true:
- Unwillingness to donate saliva sample for genetic analysis
- History of liver or bone marrow (hematopoietic cell) transplantation
- PGx testing results are already available
- No personal health identification number (PHIN) is available
This study has been approved by the Health Research Ethics Board [RITHIM/CHIPER] (HS26637(H2024:279)), Shared Health Research and Innovation (SH2024:148), and Provincial Health Research Privacy Committee (PHRPC No. P2024-103).
This study is funded by the University of Manitoba College of Pharmacy, Rady Faculty of Health Sciences, Department of Psychiatry Academic Projects Award, Kaniz Amina Mannan Research Grant, and the Health Sciences Centre Foundation.
Team:
Principal Investigator:
Abdullah Al Maruf, PhD, M.Pharm (University of Manitoba)
Senior Leads:
Jitender Sareen, MD, FRCPC (University of Manitoba)
Chad Bousman, PhD, MPH (University of Calgary)
Co-investigators/Collaborators:
Murray Enns, MD, FRCPC (University of Manitoba)
Ruth Ann Marrie, MD, PhD (Dalhousie University)
Renée El-Gabalawy, MA, PhD, C.Psych (University of Manitoba)
Sina Hafizi Barjin, MD (University of Manitoba)
Vishal Raj Kaushik, MD (University of Manitoba/Victoria Hospital)
Alexander Singer, MB BAO BCh. CCFP (University of Manitoba)
Christine Leong, PharmD, BScPharm (University of Manitoba)
Kaarina Kowalec, PhD, MSc (University of Manitoba)
Anna Chudyk, MSc, PhD (University of Manitoba) [Patient-oriented Researcher]
Shweta Mital, PhD (University of Manitoba) [Health Economist]
Daniel Yaworski, MD (University of Manitoba/Brandon Regional Health Centre)
Femi Afolabi, MD (University of Manitoba/Brandon Regional Health Centre)
Ranjit Tatineni, MD (University of Manitoba/Brandon Regional Health Centre)
Paul Arnold, MD, PhD, FRCPC (University of Calgary)
David Oslin, MD (University of Pennsylvania)
Research Pharmacists (Co-investigators/Collaborators):
Anju Sareen, BSc(Pharm) (Manager, Steele's Apothecary, College of Pharmacy, University of Manitoba)
Jaclyn To, BScPharm, ACPR (WRHA Pharmacy Program)
Erin Ramalho, BScPharm, BCPP, EPPh (Brandon Regional Health Centre)
Research Nurse:
Laina McAusland, RN, MSc (University of Calgary)
Clinical Research Coordinator:
Madison Heintz, MSW, RSW (University of Calgary)
Research Assistants:
Mahin Hasan, PhD student (University of Manitoba)
Nuzhat Tabassum, MSc Student (University of Manitoba)
Abdullah Al Maruf, PhD, M.Pharm (University of Manitoba)
Senior Leads:
Jitender Sareen, MD, FRCPC (University of Manitoba)
Chad Bousman, PhD, MPH (University of Calgary)
Co-investigators/Collaborators:
Murray Enns, MD, FRCPC (University of Manitoba)
Ruth Ann Marrie, MD, PhD (Dalhousie University)
Renée El-Gabalawy, MA, PhD, C.Psych (University of Manitoba)
Sina Hafizi Barjin, MD (University of Manitoba)
Vishal Raj Kaushik, MD (University of Manitoba/Victoria Hospital)
Alexander Singer, MB BAO BCh. CCFP (University of Manitoba)
Christine Leong, PharmD, BScPharm (University of Manitoba)
Kaarina Kowalec, PhD, MSc (University of Manitoba)
Anna Chudyk, MSc, PhD (University of Manitoba) [Patient-oriented Researcher]
Shweta Mital, PhD (University of Manitoba) [Health Economist]
Daniel Yaworski, MD (University of Manitoba/Brandon Regional Health Centre)
Femi Afolabi, MD (University of Manitoba/Brandon Regional Health Centre)
Ranjit Tatineni, MD (University of Manitoba/Brandon Regional Health Centre)
Paul Arnold, MD, PhD, FRCPC (University of Calgary)
David Oslin, MD (University of Pennsylvania)
Research Pharmacists (Co-investigators/Collaborators):
Anju Sareen, BSc(Pharm) (Manager, Steele's Apothecary, College of Pharmacy, University of Manitoba)
Jaclyn To, BScPharm, ACPR (WRHA Pharmacy Program)
Erin Ramalho, BScPharm, BCPP, EPPh (Brandon Regional Health Centre)
Research Nurse:
Laina McAusland, RN, MSc (University of Calgary)
Clinical Research Coordinator:
Madison Heintz, MSW, RSW (University of Calgary)
Research Assistants:
Mahin Hasan, PhD student (University of Manitoba)
Nuzhat Tabassum, MSc Student (University of Manitoba)
Recruitment materials are prepared by Grace and Haley. RedCap project is developed by Laina McAusland.
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